They did shake up the set pretty much at the Mohegan show 2011/03/04. You Give Love a Bad Name in spot 15. It worked pretty well, but for me it's something magical with Bad Name in the second or third spot.
When it's comes to drastic setlist changes I don't think it will be much more drastic than the Mohegan show.

1. The Radio Saved My LifeTonight
2. We Weren't Born To Follow
2. Lost Highway
4. Whole Lot of Leavin'
5. Thorn In My Side
6. Wild in the Streets
7. I Got the Girl
8. The More Things Change
9. Summertime
10. Blaze of Glory
11. In These Arms (David Vocals)
12. Superman Tonight (Ac.)
13. Living In Sin
14. Who Says
15. You Give Love a Bad Name
16. It's My Life
17. Wanted Dead or Alive (Richie 2nd verse)
18. Bad Medicine
19. Living on a Prayer
--------------------------
20. Hey God
21. Raise Your Hands

Yes, there are a couple of shitty songs in there ut overall it's kinda cool!
As a sidenote, I would love to see the band opening their set with Runaway. That could've been really cool!!