I've been on planes since I was about 1 year old so it's never really bothered me. The only thing that has bothered me in the past few years though is how claustrophobic it is (I'm pretty big, so there isn't much space for my legs, which makes it uncomfortable) In future I'd pay extra for seats with more legroom.

As Krycek said though the chance of a plane crashing is very small, a statistic I read was that more people are killed every year by donkeys than die in plane crashes. Since planes are safer than cars, plus as you said it would take 15-20x longer by car, logically it makes much more sense to travel by plane.