When you run the program select "Open Disc" and it will scan through the disc, it may take a few minutes
Then you can cut out any audio and subtitles you don't want, such as foreign languages, director commentaries, whatever you don't need (the more of such things you cut the less it needs to compress the video). It will auto set every compression.
Then you press Backup, and you select the output directory.
Then you choose the Region tab and can select which region you like or set it to region free
Finally you can set the quality settings. If you want a higher quality output it's best to run the analysis and set it to high quality, but obviously this will take longer.
Obviously make sure you have enough free hard drive space for it to save to. Then just hit OK, and dependant on what settings you used and what spec your pc is it could take 30-60 minutes.