Use Opera as browser, it has built-in popupkiller.
Another choise for those IE (yuck!) lovers might be Avant browser. Avant use IE but it is whole new user interface. hell of a lot better than plain IE.
Avant also has popup block in it, I think

Im sure u already know how to clean them spyware craps, in case u dont.
"ad-aware" or "spy bot search and destroy" will do the trick.